FIRST-IN-HUMAN STUDY OF THE SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF FIRST-IN-CLASS FATTY ACID SYNTHASE INHIBITOR TVB-2640 ALONE AND WITH A TAXANE IN ADVANCED TUMORS

Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane.Methods: This completed open-label outpatient study was conducted at 11 sites in the United States and United Kingdom.Patients with

Purpose The aim of this work was to provide data about the causes and nature of ocular trauma and to find the relationship of these causes with Camera Lens Protector age and sex.Patients and methods Patients with all types of eye injuries such as mechanical (by blunt object, sharp object, or foreign body), chemical or physical injuries were enrolle

The housing crisis in New Zealand poses severe health risks, particularly for children and vulnerable populations.Approximately 20% of homes are damp, cold, or mouldy, contributing to respiratory problems and hospitalisations.The condition of rental properties, often poorer than that of owner-occupied homes, disproportionately affects lower-income

Focusing on the domain of self-compassion, this study explored the promotion mechanism of online learning behavioral engagement (OLBE) of international students in China under COVID-19.Positive emotion and self-improvement motivation were selected as mediators.Participants were 606 international students from 8 countries who were studying online in